MyHealthspan
Advanced DNA Methylation Test
Advanced DNA Methylation Test
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$349.00
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$349.00
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A brain-specific epigenetic analysis that goes beyond overall biological age to reveal how your brain is aging at the molecular level — and what to do about it.
How It Works
1
Order online Complete your purchase and your at-home saliva collection kit ships directly to your door within a few business days.
2
Receive your kit and provide your sample Follow the clear step-by-step instructions included in your kit to collect your saliva sample. The process takes under five minutes.
3
Mail your sample back for comprehensive methylation analysis Use the prepaid return envelope to send your sample to our certified lab. Your DNA undergoes a comprehensive methylation analysis focused on brain-specific epigenetic markers.
4
Receive your cognitive health report in 2 to 4 weeks Results are delivered in your MyHealthspan app with a detailed cognitive health report. A Longevity Coach is available to support your interpretation and build your brain optimization protocol.
What You'll Learn
- Your brain's epigenetic age versus your chronological age, derived from methylation markers specifically linked to brain tissue aging
- Which biological processes are most active in your cognitive aging profile, including neuroinflammation pathways and cognitive reserve markers
- Specific methylation patterns linked to neuroplasticity, synaptic health, and long-term cognitive reserve
- A personalized brain optimization protocol grounded in your epigenetic data, covering sleep, nutrition, exercise, and targeted supplementation
What's Included
- At-home saliva collection kit, shipped to your door
- Advanced DNA methylation analysis with brain-specific epigenetic markers
- Comprehensive cognitive health report with brain age assessment
- Results delivered in the MyHealthspan app
- Longevity Coach support for interpreting results and building your brain optimization protocol
Who This Test Is For
This test is for someone who wants to go deeper than a basic biological age score and understand specifically how their brain is aging at the molecular level. It is often chosen by people with a personal or family history of cognitive decline, high-performers who rely on mental sharpness for demanding work and want to protect that edge proactively, or anyone who has already tested positive for APOE ε4 and wants a complete picture of their cognitive risk profile. It is also the natural next step for anyone who has completed the Epigenetic Age test and wants brain-specific detail that the general biological age result cannot provide. If cognitive longevity is a priority, this test gives you the most granular available window into how your brain is actually aging.
What We Analyze
This test measures DNA methylation patterns at sites specifically associated with brain aging and cognitive longevity. While the standard Epigenetic Age test produces an overall biological age estimate from genome-wide methylation patterns, this advanced analysis focuses on a curated set of epigenetic markers with particular relevance to neural function, neuroinflammation, and cognitive reserve.
Key domains assessed include methylation patterns linked to neuroplasticity (the brain's ability to form and reorganize connections), neuroinflammatory pathways (chronic low-grade brain inflammation is an established driver of cognitive aging), synaptic integrity markers, and cognitive reserve indicators associated with resilience against age-related cognitive decline. Together, these markers produce a brain-specific epigenetic age and a multi-dimensional cognitive health profile that is significantly more actionable than a single biological age number.
Doctor-founded by Dr. Zia Poonja, practicing oncologist. Every protocol is clinically designed.
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"Life-changing. I'm not kidding. The biomarker data alone gave me a sense that I should be eating better. But the coaching session helped me see the deeper patterns, uncovering key insights about my overall lifestyle. I'm just about to turn 40, and I'm so glad I did this now."Cyril K., MyHealthspan member
Frequently Asked Questions
How is this different from the Epigenetic Age test?+
The Epigenetic Age test produces an overall biological age estimate by analyzing genome-wide methylation patterns across all tissue types. It answers the question: how old are my cells overall? The Advanced DNA Methylation Test zooms in specifically on epigenetic markers associated with brain aging, neuroinflammation, neuroplasticity, and cognitive reserve. It answers a more specific question: how is my brain aging at the molecular level, and which biological processes are most relevant to my cognitive future? If you want the most complete picture of your cognitive longevity risk, doing both tests provides complementary information — the overall biological age context plus the brain-specific detail.
Does this test diagnose Alzheimer's?+
No. This test does not diagnose Alzheimer's disease or any other clinical condition. It measures epigenetic markers associated with brain aging trajectories and provides a probabilistic picture of how your brain is aging relative to expected norms. It is a risk assessment and optimization tool, not a diagnostic instrument. A clinical diagnosis of Alzheimer's requires a comprehensive neurological evaluation including cognitive testing, brain imaging, and in some cases cerebrospinal fluid or blood biomarker analysis performed by a specialist. If your results raise concerns that warrant clinical follow-up, your Longevity Coach will guide you toward the appropriate next steps.
What methylation markers are most relevant to cognitive aging?+
The most clinically relevant methylation markers for cognitive aging fall into several categories. Neuroinflammation-associated markers reflect the methylation state of genes regulating microglial activation and inflammatory cytokine expression in the brain — chronic neuroinflammation is one of the best-established drivers of cognitive decline. Neuroplasticity markers reflect the epigenetic regulation of BDNF (brain-derived neurotrophic factor) and related genes that govern the brain's ability to form new connections. Synaptic integrity markers are linked to genes governing neurotransmitter systems. Cognitive reserve markers are associated with genes linked to educational attainment and processing speed in large-scale GWAS studies. Your report will contextualize your results across these domains.
How long does it take to see changes in epigenetic markers if I change my lifestyle?+
Epigenetic changes in response to lifestyle interventions can occur on a range of timescales. Some methylation changes are detectable within weeks of sustained behavioral change — particularly in response to diet modification and stress reduction. More robust and durable shifts in biological age typically take 3 to 12 months of consistent intervention to become statistically detectable. Most people who retest do so at 12 to 18 months to give interventions sufficient time to produce meaningful epigenetic signal. The lifestyle protocol included with your results will prioritize the interventions with the strongest evidence for producing measurable epigenetic change in the brain.
Should I do this test if I already did the APOE test?+
Yes, and the combination is particularly powerful. The APOE test tells you about your genetic predisposition — the hand you were dealt. The Advanced DNA Methylation Test tells you how your brain is actually expressing that predisposition given the way you have lived. Someone with APOE ε4 who has maintained excellent lifestyle habits may show a brain epigenetic age younger than their chronological age, suggesting that their interventions are working. Someone without ε4 who has experienced chronic stress, poor sleep, or metabolic dysfunction may show an accelerated brain epigenetic age. Taken together, the two tests give you both the genetic context and the current biological reality, which is the most complete picture available for cognitive longevity planning.
Already a MyHealthspan member? Check your membership tier — this test may already be included. View membership options →
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