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MyHealthspan

Alzheimer's APOE DNA Test

Alzheimer's APOE DNA Test

$199.00
$199.00
Sale Sold out
Alzheimer's APOE DNA Test — MyHealthspan

Know your APOE genotype, understand your Alzheimer's and cardiovascular risk profile, and receive a personalized prevention strategy built around your actual genetic blueprint. $199 CAD.

How It Works

1
Order online Complete your purchase and your at-home nasal swab collection kit ships directly to your door within a few business days.
2
Receive your kit and provide your sample Open your kit and follow the simple step-by-step instructions to collect your nasal swab sample. The process takes under five minutes.
3
Mail your sample back Use the prepaid return envelope included in your kit to send your sample to our certified lab. No trips to a clinic required.
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Receive results and genetic counseling session Results are available in your MyHealthspan app in 2 to 4 weeks. A genetic counseling session is included to help you understand your result and build your personalized action plan.

What You'll Learn

  • Your APOE genotype (ε2, ε3, or ε4) and what it means specifically for your Alzheimer's risk and cardiovascular health profile
  • Which personalized prevention strategies are most relevant and most urgent based on your specific result
  • Whether lifestyle interventions like the Mediterranean diet, Zone 2 cardiovascular training, and sleep optimization should be prioritized with particular urgency given your genetic profile
  • Your baseline for ongoing cognitive health monitoring, so you can track your brain health trajectory over time with meaningful context

What's Included

  • At-home nasal swab collection kit, shipped to your door
  • APOE genotype analysis (ε2, ε3, ε4 variants) performed at a certified lab
  • Results delivered in the MyHealthspan app
  • Genetic counseling session to review your result and what it means
  • Personalized action plan based on your APOE genotype

Who This Test Is For

This test is for someone who has a family history of Alzheimer's or dementia and wants to know where they stand genetically before any symptoms arise. It is equally relevant for anyone who wants to make proactive, specific decisions about their lifestyle, diet, and supplementation based on their actual genetic profile rather than population averages. Knowledge of APOE status is among the most actionable pieces of genetic information available, because it directly shapes which prevention strategies apply to you with the greatest urgency. This test is for people who believe knowing is better than not knowing and who are ready to act on what they find. It is not a test for people who want certainty about their future — no genetic test provides that. It is a test for people who want the clearest possible foundation for making decisions today.

What We Analyze

This test analyzes the APOE gene (Apolipoprotein E), specifically the three major variant alleles: ε2, ε3, and ε4. Everyone inherits two copies of APOE, one from each parent, producing six possible genotype combinations. The ε4 allele is the strongest known genetic risk factor for late-onset Alzheimer's disease. Carrying one copy of ε4 (heterozygous) elevates lifetime risk compared to the general population; carrying two copies (homozygous ε4) elevates it further. The ε2 allele is associated with reduced Alzheimer's risk and some cardiovascular protective effects. APOE also influences how the body processes dietary fats and LDL cholesterol, making it directly relevant to cardiovascular risk stratification. Understanding your APOE genotype allows for highly targeted prevention strategies rather than generic population-level recommendations.

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"For a busy mom, it was the perfect balance of fast and slow. My blood draw was so fast, and the 1 hour call with Josh really forced me to slow down and consider how my lifestyle choices are impacting my health."
Selina V.F., MyHealthspan member

Frequently Asked Questions

What does it mean if I have APOE ε4?+
APOE ε4 is the strongest known genetic risk factor for late-onset Alzheimer's disease, but it is a risk factor, not a diagnosis or a guarantee. Carrying one copy (heterozygous) meaningfully elevates lifetime risk relative to the general population. Carrying two copies (homozygous) elevates it further. However, a large proportion of ε4 carriers never develop Alzheimer's, and many people without ε4 do. What ε4 status gives you is clarity on which prevention strategies are most important for you specifically. Evidence-based interventions including cardiovascular fitness, optimal sleep, Mediterranean-style nutrition, and active stress management are all associated with reduced Alzheimer's risk even in ε4 carriers. Your counseling session will walk you through exactly what your result means and what to do about it.
Does having APOE ε4 mean I will get Alzheimer's?+
No. APOE ε4 increases risk but does not determine destiny. Alzheimer's is a complex, multi-factorial disease influenced by genetics, lifestyle, environment, and other health conditions. Many people with one or even two copies of ε4 live long lives without developing cognitive decline. Conversely, people with no ε4 alleles can still develop Alzheimer's. What makes APOE testing valuable is that it gives you a precise, personalized risk signal that most people never receive, allowing you to prioritize the lifestyle factors with the greatest impact for your specific profile, decades before any symptoms could appear.
Is genetic counseling included?+
Yes. A genetic counseling session is included with this test to ensure you receive your result in the right context and with the support to understand what it means for your health. You will not be left to interpret a sensitive genetic result alone. Your counselor will explain your APOE genotype, discuss the associated risks in clear terms, and help you understand what actions are most relevant to your specific result. If you want to go deeper into genetic counseling as part of a broader hereditary risk assessment, the Hereditary Risk DNA Test includes a full 1-hour certified genetic counselor consultation.
How is this different from a 23andMe test?+
Consumer genetics companies like 23andMe do report some APOE-related information, but they typically do not provide full APOE genotyping, and they do not include clinical-grade counseling or personalized action plans. The MyHealthspan APOE test is performed at a certified clinical laboratory and is accompanied by a dedicated counseling session specifically focused on what your result means for your health and what you should do about it. The goal is not just a data point — it is a clinically supported, actionable result that integrates into your broader health picture.
What do I do if my result shows elevated risk?+
Your genetic counseling session is specifically designed to answer this question. Your counselor will walk you through what elevated risk means in practical terms, which lifestyle interventions are most supported by evidence for your specific genotype, and whether any clinical follow-up or specialist referrals are appropriate. Many members who receive an ε4-positive result go on to take additional steps such as the Advanced DNA Methylation Test for brain biological age, deeper cognitive benchmarking, or more intensive longevity coaching. Your counselor will help you determine the right next steps for your situation.

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